|Family|| Daughter: Helen Seinfeld
Son: Uncle Leo
Granddaughter: Unnamed granddaughter
Son-in-law: Morty Seinfeld
|First Appearance||"The Pledge Drive"|
|Last Appearance||"The Doodle"|
|Portrayed By||Billye Ree Wallace|
Nana (real name unknown) is Jerry's grandmother and the mother of Helen Seinfeld and Uncle Leo. When her mind starts to mix up the present and the past, she reveals that Uncle Leo owes his sister, Jerry's mom, $50 from a racetrack bet their father won when they were kids. Nana's real name is never said, but Jerry always refers to her as Nana. Nana was portrayed by Billye Ree Wallace.
Nana sends Jerry a check for $10 every year for his birthday. When Jerry decides to cash them in (years later), due to her not using Chemical Bank anymore, she is overdrawn and therefore has to go refund it. She gets lost, and Leo believes that she is missing.